Why scientists are rethinking the most effective way to treat depression

An “important molecule of interest” is a bridge between two competing ideas.Getty ImagesSARAH SLOAT8.22.2021 9:00 AM

THE FDA APPROVAL and emergence of selective serotonin uptake inhibitors (SSRIs) in the late 1980s transformed psychiatry. Finally, there was an effective and inexpensive medication for depression, a leading cause of disability worldwide. Today SSRIs are some of the most widely prescribed drugs.

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